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The newly reformed acyl-CoA is now perfectly positioned to enter the beta-oxidation pathway, a series of chemical reactions that break down the fatty acid chain to generate Acetyl-CoA, NADH, and FADH2

Lipid peroxidation and the total antioxidant status in the pathogenesis of age related and diabetic cataracts: a study on the lens and blood

For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

However, if taking it on an empty stomach causes mild gastrointestinal upset, taking it with a small, light carbohydrate snack can mitigate this issue without severely compromising absorption