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220,258,259 While the efficacy of statins in alleviating DPN symptoms remains unclear, 260,261 emerging lipid-lowering therapies showed potential in improving nerve function in DPN models

PLPUFAs are subsequently oxidized by ALOX or other oxidases (e.g., CYP450 and prostaglandin-endoperoxide synthase 2) to form lipid peroxideskey signaling molecules that drive ferroptosis