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In agreement with these studies, some animal studies have indicated that antioxidants may increase the risk of cancer and accelerate the development of primary lung tumors (Le Gal et al

identified a novel cytokine profile associated with metastasis of NSCLC to TDLNs using EBUS TBNA ( 5.2 Cellular involvement in the nodal microenvironment The implications of varying cellular compositions of the TDLN microenvironment has been the subject of multiple studies in NSCLC (see Table 1 )