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Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

DIV day in vitro Hippocampal slices which were biolistically transfected with the soluble red fluorescent protein Tomato were stimulated with 10 ng/ml HGF, 10 12 M Dihexa or vehicle for 48 hours

Microinjection of l-arginine into corpus callosum cause reduction in myelin concentration and neuroinflammation