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Nature 2021;595:701-6

doi: 10.1074/mcp.M200025-MCP200 132 PappT.VelayosA.BartkT.EslavaA

In addition, 5,10-methylene tetrahydrofolate formed by photorespiratory metabolism is more easily interconvertible to 5-methyl tetrahydrofolate because photorespiration generates NADH in the mitochondria, thereby facilitating methionine synthesis 21

When estrogen and progesterone levels rollercoaster during perimenopause, and starts to decline overall, the brain has fewer chemical tools to cope with stressors, which can result in anxiety