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Investigators have assessed multiple administration routes, including subcutaneous, intramuscular, intravenous, oral, and topical delivery in experimental models

These proteases include thrombin [141,142,143,144], factor Xa [141,145], enterokinase [146], human rhinovirus (HRV) 3C protease/PreScission Protease [147], and tobacco etch virus (TEV) protease [148]