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At least one-way GCKR P446L increases TG in liver may be by increasing ChREBP, ACC and FASN protein levels to increase de novo lipogenesis

Personalized Glutathione Protocols and Precision Medicine The future of injectable glutathione therapy likely involves increasingly personalized approaches that account for individual genetic variations affecting glutathione metabolism, baseline glutathione status assessed through specialized testing, specific oxidative stress burdens based on environmental exposures and lifestyle factors, health goals and priorities that vary among individuals, and response patterns to glutathione therapy including dosing requirements and optimal administration routes

As of this writing, the only intervention available that appears promising for lowering Lp(a) is lipoprotein apheresis

doi: 10.1111/and.13525