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However, there is only one approved drug, setmelanotide for POMC-LEPR deficiency [10], and there is no treatment for other POMC-MC4R pathway-deficient diseases, such as POMC-null, MSH-deficiency, and patients with PWS with obesity

Thats not a risk-reward calculation Id sign off on, and I dont think you should either, at least not without doing something about the unregulated half of the equation

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MOTSc is studied in preclinical models to better understand metabolic signaling (how cells coordinate energy use), cellular energy regulation (how cells respond when energy demand changes), and mitochondrial homeostasis (how mitochondria maintain stable function)