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Ischemia-induced glutamate excitotoxicity depletes cystine availability, compromising glutathione synthesis and inactivating GPX4, thereby removing the critical brake on lipid peroxidation

Gardembas M, Rousselot P, Tulliez M, Vigier M, Buzyn A, Rigal-Huguet F, Legros L, Michallet M, Berthou C, Cheron N (2003) Results of a prospective phase 2 study combining imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukemia in chronic phase

**Pediatric patients, 6 years of age or older, with moderate to severe plaque psoriasis, and weighing at least 20 kg

Animal studies suggest anti-inflammatory effects, but human evidence is lacking