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Diverse Compounds From Pleuromutilin Lead to a Thioredoxin Inhibitor and Inducer of Ferroptosis

Glia 27, 110128

Accumulated ROS also activate the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome, initiating caspase-1-mediated pyroptosis and amplifying immune-mediated hepatocyte injury

Inhibition of NFS1, which is required for primary lung tumor growth, limits the availability of ISC and strongly activates the iron deficiency response [112]