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The gut microbiota and CVDs The human gut is colonized by approximately 100 trillion microorganismsincluding beneficial bacteria, neutral bacteria, and pathogenic bacteriawhich cooperate to maintain homeostasis of the gut microecology ( Bacteroidetes and Firmicutes account for approximately 90% of the total gut microbial abundance, followed by Proteobacteria (5-10%), Actinobacteria (3%), and Verrucomicrobia ( Intestinal dysbiosis refers to imbalance in the composition and abundance of gut microbiota and is associated with numerous diseases and phenotypes ( Supplementary Table 1 )