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Despite demonstrated efficacy in vitro , curcumin's poor aqueous solubility, chemical instability at physiological pH, and extensive metabolism result in barely detectable plasma concentrations after oral administration (164167)

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The high CD38 + NK cells and low CD38 + NK-like T cells from the synovial fluid of RA patients suppress Treg cell differentiation by stimulating mTOR signaling in CD4 + T cells (74)

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