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Tsai, Bioinspired, manganese-chelated alginate-polydopamine nanomaterials for efficient in vivo T1-weighted magnetic resonance imaging

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28 Excessive ROS production leads to an oxidative inactivation of anti-proteases, alveolar epithelium damage, increased neutrophil retention and increased expression of various inflammatory mediators in the pulmonary microcirculation, aggravating the development of COPD