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doi: 10.3389/fnut.2025.1679494 Received 04 August 2025 Revised 19 October 2025 Accepted 25 December 2025 Published 22 January 2026 Volume 12 - 2025 Edited by Manuela Machado, Escola Superior de Biotecnologia - Universidade Catlica Portuguesa, Portugal Reviewed by Ivan oa, University of Rijeka, Croatia Moumita Saha, Yale University, United States Updates Copyright 2026 Chang, Lin, Renn, Liu, Yen, Liao, Tikhonova, Amstislavskaya, Singh and Chen

There are also under the tongue and intranasal methods that can be used once B12 levels are normalized

Visceral adipose tissue, the deep fat wrapped around organs in the abdominal cavity, has its own receptor profile, its own hormonal sensitivity, and its own stubborn resistance to standard calorie deficits