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The effectiveness of compound X is often dependent on the presence of compounds Y and Z and so on

The global sensitivity analysis also confirmed the importance of the redox cycle between SQ . and H 2 Q ( R 4 ), showing that the reverse rate constant, k m4 (SQ . reformation), was the second most sensitive (main interactions) with respect to model OCR and therefore ROS production, suggesting auto-oxidation is an essential part of the doxorubicin redox mechanism

MCT1 and MCT4 mediate export and import of lactate, but without CD147 association, they accumulate in the perinuclear region and are finally degraded by the proteasome (Kirk et al., 2000

(f) evasion of the immune system and