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Additional information Peptide Research Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity (2017) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design (2010) In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin (2015) (related to spadin mechanisms applicable to analogs) Spadin as a new antidepressant: absence of TREK-1-related side effects (2012) The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin (2018) Role of TREK-1 in Health and Disease, Focus on the Central Nervous System (2019 review) Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4F or colder for optimal long-term stability in research settings

Rare but Serious: Pseudoseptic Arthritis In very rare cases, patients develop pseudoseptic arthritisa condition that mimics joint infection but isnt caused by bacteria

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Recognizing these symptoms early allows for faster treatment and better outcomes