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They also determined that IR inhibits Ferritin Heavy Chain 1 (FTH1) expression [38], once again implicating the role of iron storage disruption in IR-induced ferroptosis progression

In contrast, carboplatin-paclitaxel remains the backbone of first-line therapy in ovarian cancer, with phase III trials showing mOS up to 44.8 months and mPFS of 16.2 months (NCT00028743) [134]