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doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al

Those with growth hormone deficiencies or age-related health issues may benefit from IGF-1 therapy under medical supervision

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

This difference in treatment effect for pemetrexed based on histology demonstrating a lack of efficacy in squamous cell histology was also observed in Studies JMEN and JMEI