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For limited or localized disease, potent topical corticosteroids remain as first-line treatment, with topical calcineurin inhibitors as steroid-sparing options, especially for sensitive areas

Symptoms of acute, explosive watery diarrhea are to be expected at this stage of operation of the defensive program

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These injections are typically administered intramuscularly , although some protocols allow for MIC B12 injections to be administered subcutaneously or intramuscularly , depending on clinical preference