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It reduced urinary albumin in diabetic mice, improved renal tissue damage, alleviated renal fibrosis, reduced iron content in the renal tubules, increased p-AMPK/t-AMPK levels in the kidneys, inhibited the formation of ROS in the kidneys, reduced the expression of gp47 phox in the kidneys, leading to decreased MDA expression and increased SOD, CAT and GSH-PX expression, and increased the expression of GPX4 in the kidneys

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Research Highlights Metabolic Regulation and Anti-Obesity Effects: Potent inhibition of nicotinamide N-methyltransferase (NNMT) increases cellular NAD and S-adenosylmethionine (SAM) levels, enhances polyamine flux, boosts energy expenditure, and suppresses lipogenesis

High-quality protein: Grass-fed meats, wild-caught fish, and organic eggs provide the necessary amino acids