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Synthetic color for example chocolate color agents decrease rat body weight, serum cholesterol and HDL cholesterol and increase liver enzyme [8,9] Food colorants (amaranth, erythrosine and tartrazine) had a toxic potential to human lymphocytes in vitro and seems that they bind directly to DNA [10]

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For example, in neonatal and adult heart tissues, fibroblasts arise from endogenous cell populations via epithelial to mesenchymal transition (EMT) and from bone marrow derived cells (Visconti et al., 2006)

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