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doi: 10.3389/fnins.2026.1731771 Received 24 October 2025 Revised 19 January 2026 Accepted 21 January 2026 Published 03 February 2026 Volume 20 - 2026 Edited by Heather Jane Mortiboys, The University of Sheffield, United Kingdom Reviewed by Abhishek Balmik, Emory University, United States Avital Schurr, University of Louisville, United States Updates Copyright 2026 Pang, Yang, Liu, Xie and Wang

[DOI] [PMC free article] [PubMed] [Google Scholar] [64].Ding Y, Chen X, Liu C, et al

Hecquet S, Totoson P, Martin H, et al

2.2 Intra-VLP nucleic acid encapsulation technologies While Section 2.1 Extra-VLP protein antigen display technologies detailed the spatial orchestration of surface antigens to dictate immune recognition, the interior lumen of the VLP offers a sequestered and shielded microenvironment for the encapsulation of functional nucleic acids, such as immunostimulatory CpG oligonucleotides or therapeutic mRNA