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doi: 10.1152/ajpheart.00381.2014 168 HuangWXieZ

ALOX15 is essential for ferroptosis induced by compounds (e.g., erastin or RSL3), as it forms a complex with PE binding protein 1 (PEBP1), specifically recognizing stearoyl-arachidonoyl-phosphatidylethanolamines and generating lipid peroxides [103]