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Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter

Based on the important role of ferroptosis in AD pathogenesis, inhibiting ferroptosis has become a significant strategy to reduce neuronal damage in AD in preclinical studies

M.), AG13925 (J.L.K.), AG041122 (J.L.K.), AG31736 (Project 4: J.L.K.), and AG044396 (J.L.K.), Robert and Arlene Kogod, the Connor Group (J.L.K.), Robert J

Molecular dynamics simulations of GLRX and complexes Using the crystal structure of GLRX (PDB ID: 4RQR, Uniprot ID: P35754), we constructed models of GLRX wild type and mutants (C83S, C8S, and C79S) as well as the GLRX dimers for molecular dynamics (MD) simulations, using Protein Preparation Wizard (Pymol, Schrdinger, Inc.) and the relaxation strategy in our prior work 52