glutathione persister cells cancer Drug-tolerant are vulnerable to GPX4 inhibition Oncology Reports

Inadequacies in antioxidant enzymes or their compromised metabolism will increase the concentration of reactive oxygen species (ROS) and, in essence, cause oxidative stress

Linkage disequilibrium across the UGT1A locus should not be ignored in association studies of cancer susceptibility

Mutations in the gene encoding Cu/Zn superoxide dismutase 1 ( SOD1 ) is found in a small percentage of familial ALS

Modifications in neurotransmitter levels by modulatory pathways such as the kynurenine pathway, and also changes in accessibility and effects of SCFAs in the brain, may have an impact on BDNF activities such as neural survival and CNS development (70)