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CLIP6-PNA-peptide conjugates: non-endosomal delivery of splice switching oligonucleotides

S., Mishra, S

While lipid peroxides and high iron levels have been detected in the lungs of cystic fibrosis patients, it remains unclear to what extent ferroptosis may be involved in the initiation and maintenance of disease, but better understanding of how ferroptosis contributes to the pathophysiology of cystic fibrosis lung disease is critical and may provide the impetus to new therapeutic interventions

In an adverse circumstance, if Q A has been reduced to the point where it cannot accept any additional electrons, the excited state 3 P680* is formed when 3 (P680 + Pheo ) recombines with P680 ( 3 P680*