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In malignant tumors, IFN produced by CD8+ T cells increases with rising Gln concentrations, indicating that immunotherapy targeting tumors also relies on Gln-dependent activation of CD8+ T cells ( In the microenvironment of liver cancer tumors, Gln deficiency promotes the invasion of myeloid cells expressing the immunosuppressive receptor GPR109A, facilitating immune evasion

Similarly, dietary intake of - N -oxalyl-amino- L -alanine (BOAA), a plant-derived excitotoxin and potent agonist of ionotropic glutamate receptors, induces lathyrism, a neurodegenerative disease characterized by irreversible motor dysfunction due to spinal cord damage [96]

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