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While these studies all modeled injuries that are more severe than concussions, there was one experimental study that measured CMRglc after concussive-like injuries in the adolescent rat

The recommended dose is 400mg (which requires the inhalation of the content of 10 capsules loaded individually into the inhaler) twice a day, once in the morning and once in the evening.12 Mannitol has the advantage of being a powder formulation and therefore has a shorter delivery time which avoids the usual maintenance and cleaning issues related with nebulizer devices

Oxidative Medicine and Cellular Longevity, Article ID: 5716409

However, many clinicians and some researchers feel there is a large grey zone between 160-500 pmol/L, which in some patients could represent functional deficiency on a cellular level