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Because we observed fewer SMA + cells in Mock tumors than VEGFR2-Fcexpressing tumors in both models, these cells, during chronic exposure to anti-VEGF therapy, might be recruited from blood into the tumor microenvironment by secreted factors or might be differentiated from other cell types in the tumor microenvironment

When B 12 is administered in doses which saturate the binding capacity of plasma proteins and the liver, the unbound B 12 is rapidly eliminated in the urine

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