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Interestingly, the effect of ABCA1 deficiency on AD-like phenotype only occurs in apoE4 expressing mice, but not in apoE3 expressing mice (Fitz et al., 2012)

Int J Neuropsychopharmacol (2007) 10:54755.10.1017/S1461145706007322 163 VostrikovVMUranovaNAOrlovskayaDD

Reconstitution: Add 3.0 mL bacteriostatic water ~3.33 mg/mL concentration Typical Daily Dosage Range: 300500 mcg (gradual titration) Measurement Guide: At 3.33 mg/mL, 1 unit = 0.01 mL 33.3 mcg (U-100 insulin syringe) Storage: Lyophilized: Store at 20C (4F) After reconstitution: Refrigerate at 28C (35.646.4F) Avoid repeated freezethaw cycles Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Administer once daily via subcutaneous injection

Sappanone A similarly combats inflammation and ECM degradation in OA by attenuating chondrocyte ferroptosis through the SIRT1/Nrf2 pathway (165)