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2.2.2 Key driving factors 2.2.2.1 Iron overaccumulation The core driving factor of ferroptosis is the excessive accumulation of iron, and this process is mainly regulated by iron homeostasis regulators such as transferrin receptor (TFR), ferritin, and ferroportin (FPN) (Zhang et al., 2025c)

Nutrition and exercise play a key role in weight management and therefore dogs can benefit from special nutrition, like Eukanuba Overweight/Sterilised, to help achieve a lean body and enjoy activity

Finally, varying frequencies, intensities, and durations of VNS may yield different therapeutic effects

Wang F, So KF, Xiao J, Wang H