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In contrast to the delayed colonization of the brain, fungal burden increased in the lungs, liver, spleen, and kidneys of mice infected with gsh2 mutants 26 days post-infection, suggesting that gsh2 -infected mice likely succumbed to cryptococcal pneumonia and/or visceral organ damage rather than brain infection (Extended Data Figs

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This allows you to assess your tolerance to the GLP-1 agonist and manage any initial GI side effects before adding the second compound