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Therefore, we may identify novel strategies for immunotherapeutic intervention in autoinflammatory diseases and their accompanying associated disorders by thoroughly understanding the mechanisms inherent to urate-induced dysregulation of immune cells and disease advancement

on struvite crystal (kidney stone) J

2016 Nov;139(4):64050

This review synthesizes evidence that probiotics mitigate UC through multiple synergistic mechanisms: competitive exclusion to rebalance the microbiota, upregulation of tight junction proteins to restore the intestinal barrier, and bidirectional immunomodulation to restrain excessive inflammation