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Yang GY, Xu ZG, Peng SB, Sun YD, Jia CX, Zhai MZ

Consider the typical metabolic patient profile presenting to a clinic like Meto: Waking at 24 AM with an inability to return to sleep (a cortisol signature) Carrying visceral abdominal fat despite dietary effort Elevated fasting glucose or rising HbA1c despite reasonable lifestyle habits Fatigue despite adequate total sleep hours Poor recovery from exercise Blunted GH response (often confirmed on labs as low IGF-1) Each of these findings is consistent with slow-wave sleep deprivation and HPA axis dysregulation

This study is the first to use a virtual spatial navigation task to explore the relationship between diabetes-related factors and spatial cognitive performance in adolescents with type 1 diabetes

To exclude the possibility of extracellular interactions between EPS and MPP + in vitro, we performed LCMS/MS analysis on the mixture of EPS and MPP +