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But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness Heart palpitations and shortness of breath Pale skin A smooth tongue Constipation, diarrhea, loss of appetite, or gas Nerve problems like numbness or tingling, muscle weakness, and problems walking Vision loss Mental problems like depression, memory loss, or behavioral changes Treatment If you have pernicious anemia or have trouble absorbing vitamin B12, you'll need shots of this vitamin at first

TB4 and, by extension, TB-500 may work on a cellular level to reduce inflammation by regulating autophagya process of cellular waste disposal [28]

High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels