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The safety and pharmacological characteristics of statins are well known because of their long-term use in clinical practice, which is beneficial for the use of statins to treat cancers expressing mutant p53

reported that the compound IMA-1, which disrupts the interaction between ALOX12 and ACC1 (acetyl-CoA carboxylase 1), can reduce NASH progression in mice and Cynomolgus macaques, 258 suggesting that the ALOX12-ACC1 complex may be a clinically viable target for the management of NASH

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T2D is a metabolic disorder whereby the balance between insulin responsiveness of peripheral tissues and pancreatic -cell insulin secretion is dysregulated