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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

Using plain sterile water means reconstituting a fresh vial every 24 hours and wasting the remainder

Fedacko et al., 2007) via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, a key enzyme in the mevalonate pathway implicated in cholesterol and CoQ biosynthesis, and reduction in mitochondrial complex III activity of the electron transport chain (Schirris et al., 2015)

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