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doi: 10.3389/fphar.2022.908772 Received 31 March 2022 Accepted 10 May 2022 Published 24 May 2022 Volume 13 - 2022 Edited by Xu Chen, Guilin Medical University, China Reviewed by Yin Lin Ge, Qingdao University, China Pengyu Chang, First Affiliated Hospital of Jilin University, China Updates Copyright 2022 Zhang, Hou, Chen, Kan, Han, Zhang and Sun

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Main Research Findings 1) Treatment with FOXO4-DRI was found to reduce age-related testosterone secretion insufficiency in aged animals by targeting Leydig cells