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Urolithin A (UA), a metabolite derived from ellagic acid through gut microbiota metabolism, has emerged as a compelling anticancer agent

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This overview is based on previously conducted studies and does not contain new data/results of human participants or animals performed by the authors

Currently, there are two main modes of construction of AD mouse models: genetically modified models (e.g., genetic manipulation of fibrillin-1 or transforming growth factor receptor 1/transforming growth factor receptor 2 mutations) (67, 68) and chemically induced models [e.g., administration of Ang II, calcium chloride, elastase, or -aminopropionitrile (BAPN)] (69, 70)