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However, their activity decreases with aging, creating an imbalance between oxidative damage and repair mechanisms.12 Excessive accumulation of reactive oxygen species (ROS) within hair follicle melanocytes leads to cellular damage through lipid peroxidation, DNA strand breaks, mutations, and protein and enzyme denaturation

What to make of that The honest read: AOD-9604 showed real fat-loss signals in smaller, shorter trials, but couldnt hold up in a larger, longer, more rigorous study

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10.1007/s00213-016-4218-9 23 CaoJ.BoucherW.KempurajD.DonelanJ