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Demethylation therapy may lead to cytotoxicity and various side effects, while optimizing the dosage and treatment duration for MAT-targeted therapy, improving drug delivery methods, and addressing potential drug resistance issues require further investigation

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J Toxicol Clin Toxicol

Various factors such as hypoxia and infection induce activation of epithelial cells, leading to lymphocyte infiltration (especially CD4 + T cells) and release of inflammatory factors, thereby contributing to the pathogenesis of SS (191)