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Overview of ferroptosis Mechanism of ferroptosis Dysfunction iron metabolism and oxidation of lipids Many biochemical and metabolic activities rely on Fe 2+ , including energy metabolism, oxygen transport, and the cellular mitochondrial synthesis of iron-sulfur proteins

Moreover, animal studies have reported that pre-treatment with metformin could reduce both myocardial and cerebral I/R injury (203, 204)

Many of the approved covalent drugs were discovered through serendipity

Heme has many uses, as it is a cofactor in several important genes in both human cells and microbes, including, as we have described, sulfite oxidase