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(2022) provided a very comprehensive overview of animal models of PTSD and suggested modifications to simplified animal paradigms to account for myriad cognitive factors affected by PTSD, which may contribute to providing a more comprehensive recapitulation of the human experience of trauma in laboratory research (Dunsmoor et al., 2022)

SP-derived iron produced OH and NO in IL-4-induced BMDMs/RAW264.7 cells, detected by CLSM (OH, DCFH-DA probe) and Griess kit (NO), which remodeled M2-to-M1 phenotype and formed a positive feedback loop between ROS production and M1 polarization, thus delaying 4T1-bearing breast tumor growth (Fig