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We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]

cefuroxime, ceftriaxone, ceftazidime) have a lower propensity for cross reactivity, as they have different side chains to penicillin, which contribute to the decreased immunogenic ity [26]

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Because it induces pulsatile growth hormone secretion mimicking natural rhythms, timing relative to meals and sleep may influence efficacy and response patterns