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Description

Cancer cells resistant to a wide range of chemo-, targeted- and even immuno-therapies, are particularly susceptible to killing by ferroptosis inducers such as GPX4 inhibitors

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The disease is characterized by glutathionuria, which is due to the increased excretion of glutathione in the urine, low GGT activity in the serum, and higher levels of plasma glutathione

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Furthermore, the long non-coding (lnc)RNA lnc-MRGPRF-6:1 has been identified as a promoter of ox-LDL-induced macrophage ferroptosis through the inhibition of GSH peroxidase 4, thereby influencing the progression of atherosclerosis (111)

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