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TB-500, due to its larger molecular weight (~4963 Da vs ~1419 Da), is more susceptible to proteolytic degradation and aggregation

Collectively, NOXs and the ETC generate roughly 85% of H 2 O 2 , with the remaining production deriving from oxidases in the endoplasmic reticulum (ER) and peroxisomes, as well as from cumulative environmental stressors such as UV or ionising radiation 8,40,42,43