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JAMA 311 , 15471555 (2014)

The mean age of the study patients was found to be 32.90 7.92 years which was similar to the studies by Kumar et al .,[] Garg et al .,[] and Achar and Rathi.[] The disease duration of melasma in majority of patients (56.0%) was between 1 to 3 years, which is in concordance with the study by Kumar et al .[] Similar to the study by Khurana et al ., majority of patients (78%) in our study were found to be of Fitzpatrick skin type IV, followed by Fitzpatrick skin type V and type III.[] The assessment of mean difference in VAS over both cheeks before and after TA (right cheek) and glutathione (left cheek) revealed that both the treatment options were effective [Table 2]

Retinoids also make your skin more sensitive to the sun in the first few weeks, so wear sunscreen every morning and protect your skin from direct sun while you build up tolerance