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Consequences include membrane dysfunction, mitochondrial impairment, and increased susceptibility to cellular injury

When damaged mitochondria exceed the capacity of mitophagy and fusion mechanisms, cells ultimately succumb to apoptosis or necrosis under the dual assault of energy failure and persistent inflammation

Non radicals Hydrogen peroxide (H 2 O 2 ) H 2 O 2 is an important ROS molecule primarily produced intracellularly through enzymatic reactions, notably by NOX family enzymes which are key dedicated generators of ROS [71]

We conclude that NAC protected against phosgene-induced lung injury by acting as an antioxidant by maintaining protective levels of glutathione, reducing both lipid peroxidation and production of arachidonic acid metabolites