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In all of these cases the authors noted activation of transcription factors Msn2/4p, key regulators of the general stress response, a programme which involves multiple genes and their effectors implicated in protection against damage to cell structures, repair of damaged biomolecules, import of primary and alternative energy and carbon sources, and the utilization of their intracellular reservoirs

Firstly, copper can catalyze the production of ROS when present in excess, leading to oxidative stress 198,199,200 (Fig

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