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Under oxidative stress, GSH undergoes dimerization to form GSSG [10]

Interestingly, the pharmacological inhibition of GSK-3 by lithium activates NrF2, providing plausibility for certain aspects of lithiums mechanism of action to occur through ferroptosis inhibition through the GSK-3/ NrF2 pathway [173]

1,2 A variety of chemotherapy classes, with varying effects by agent within a class, are known neurotoxins with a different affinity for nerves ( Table 1 )